Compugen Stock Price, News & Analysis

Compugen (NASDAQ: CGEN) reported its Q4 and full year 2024 results, highlighting significant progress in its cancer immunotherapy pipeline. The company is set to initiate a randomized adaptive platform trial for COM701 maintenance therapy in platinum-sensitive ovarian cancer in Q2 2025. Clinical data from SITC 2024 supports the further development of COM701 as a first-in-class anti-PVRIG antibody.

Financial highlights include a strong cash position of $103.3 million as of December 31, 2024, with runway expected into 2027. The company reported revenues of $27.9 million for 2024, compared to $33.5 million in 2023. Net loss for 2024 was $14.2 million ($0.16 per share), improved from $18.8 million ($0.21 per share) in 2023.

Partner developments include AstraZeneca's expansion of the rilvegostomig program to seven Phase 3 trials, and Gilead's initiation of Phase 1 trials for GS-0321, which triggered a $30 million milestone payment to Compugen in 2024.

Compugen (Nasdaq: CGEN) reported its Q4 and full-year 2024 results, highlighting significant progress in its cancer immunotherapy pipeline. The company presented promising clinical data at SITC 2024 for COM701, their first-in-class anti-PVRIG antibody, and plans to initiate a randomized trial for ovarian cancer treatment in Q2 2025.

Key developments include:

• First patient dosed in Phase 1 trial of GS-0321 (previously COM503) licensed to Gilead
• Partner AstraZeneca expanded rilvegostomig program to seven Phase 3 trials
• Strong financial position with $103.3 million cash balance as of December 31, 2024
• 2024 revenues of $27.9 million compared to $33.5 million in 2023
• Net loss of $14.2 million for 2024, improved from $18.8 million loss in 2023

The company's cash runway is expected to fund operations into 2027, supported by milestone payments from partnerships with AstraZeneca and Gilead.

Compugen (NASDAQ: CGEN), a clinical-stage cancer immunotherapy company specializing in computational target discovery, has announced its upcoming participation in the Leerink Partners Global Healthcare Conference. The company will engage in a fireside chat scheduled for March 11, 2025, at 8:00 AM ET in Miami Beach, Florida.

Investors and interested parties can access a live webcast of the presentation through the events page in the Investor Relations section of Compugen's website (www.cgen.com). A replay option will be made available after the live event concludes.

Compugen (NASDAQ: CGEN) has announced the enhancement of its AI/ML predictive computational discovery platform, Unigen™, through collaboration with Ultima Genomics' single cell sequencing technology. The partnership combines Compugen's platform with Ultima's UG 100™ sequencing platform to gain deeper insights into tumor biology and immune regulation.

Key findings presented at the AGBT 2025 General Meeting revealed high consistency in single-cell expression levels between Ultima's UG 100 and Illumina's Novaseq 6000 platforms. The UG 100 demonstrated superior capability in identifying 3' mRNA transcript endings, potentially advancing the understanding of gene structure in tumor biology.

The collaboration aims to leverage Ultima's technology for developing proprietary single cell atlases to accelerate new immunotherapy discoveries. The research findings contribute to Unigen's predictive models, with potential applications in developing new cancer immunotherapies.

Compugen (CGEN) has announced it will release its fourth quarter and full year 2024 financial results on Tuesday, March 4, 2025, before U.S. markets open. The clinical-stage cancer immunotherapy company will host a conference call and webcast at 8:30 am ET, where management will review financial results and provide a corporate update.

Investors can access the conference call by dialing 1-866-744-5399 from the U.S. or +972-3-918-0644 internationally. A live webcast will be available through Compugen's website, with a replay accessible afterward.

Compugen (NASDAQ: CGEN), a clinical-stage cancer immunotherapy company specializing in computational target discovery, has announced its upcoming participation in the Oppenheimer 35th Annual Healthcare Life Sciences Conference. The company's management will engage in a fireside chat during the virtual conference on February 11, 2025, at 8am ET.

Investors and interested parties can access a live webcast of the presentation through the Investor Relations section of Compugen's website at www.cgen.com. For those unable to attend the live session, a replay will be made available after the event.

AstraZeneca and Daiichi Sankyo have initiated the TROPION-Lung12 Phase 3 trial, dosing their first patient to evaluate DATROWAY® (datopotamab deruxtecan) plus rilvegostomig or rilvegostomig monotherapy versus standard of care. The trial targets patients with stage 1 adenocarcinoma non-small cell lung cancer (NSCLC) after complete surgical resection who are ctDNA-positive or have high-risk pathological features.

Currently, stage 1 NSCLC treatment involves tumor resection, but up to 40% of patients may experience disease recurrence. While observation typically follows resection, adjuvant chemotherapy and/or immunotherapy may be offered to high-risk stage 1b patients. The trial aims to explore DATROWAY's potential role in combination with immunotherapy as an adjuvant treatment to prevent disease recurrence.

Compugen (NASDAQ: CGEN) has announced the dosing of its first patient in a Phase 1 clinical trial for COM503, a potential first-in-class antibody against IL-18 binding protein licensed to Gilead Sciences. The multi-center trial will evaluate COM503's safety, tolerability, and pharmacokinetics both as a monotherapy and in combination with Gilead's anti-PD1, zimberelimab, in patients with advanced solid tumors.

The trial, initiated in Q4 2024, represents a new approach to cancer treatment through cytokine biology. Compugen's Unigen™ discovery engine identified high IL-18 expression in cancer patients' tumors, but found its anti-tumor activity is blocked by an endogenous IL-18-binding protein. COM503 works by blocking this protein, potentially enabling naturally occurring IL-18 to fight cancer within tumors, addressing limitations of systemic cytokine administration.

The first patient was dosed at the START Center for Cancer Research-Midwest in Grand Rapids, Michigan, with Compugen responsible for conducting the Phase 1 trial.

Compugen (NASDAQ: CGEN) has been granted a new U.S. patent (No. 12152084) covering the triple combination use of its COM902 anti-TIGIT antibody with anti-PD-1 and anti-PVRIG antibodies for cancer treatment. The patent strengthens Compugen's IP portfolio and protects the use of COM902, a reduced Fc clinical-stage antibody, in combination with any anti-PD-1 and anti-PVRIG antibodies. The patent is set to expire no earlier than August 2037.

The company highlights that recent developments suggest potential advantages of anti-TIGITs without active Fc binder, like COM902. Their data indicates blocking TIGIT alone may be insufficient for optimal anti-tumor activity in certain cases, particularly in tumors non-responsive to PD-1 inhibition.